Pulsatilla saponin D

Research use only, not for human use.

Pulsatilla saponin D has exhibited potential beneficial effects as a chemopreventive agent for critical health conditions including cancer and it inhibits cell growth via cell cycle arrest and apoptosis in various cancer cell types.

Pulsatilla saponin D has exhibited potential beneficial effects as a chemopreventive agent for critical health conditions including cancer and it inhibits cell growth via cell cycle arrest and apoptosis in various cancer cell types.

Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase. Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells. Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) .Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF.Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells. Cell Cytotoxicity Assay Cell Line:A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells.Concentration:0.3 ng/mL to 10 μg/mL.Incubation Time:72 h.Result:Exhibited an ED50 value of 6.3 μg/mL for A-549 cells.

Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model. Animal Model:2x2x2 mm3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice.Dosage:6.4 mg/kg.Administration:Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day.Result:Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%).

Hederacolchiside A | SB365

Others

Other Targets

Others

Cancer

Colorectal Cancer; Liver Cancer; Non-small cell lung Cancer

68027-15-6

913.11

C47H76O17

>98% (HPLC)

DMSO:40 mg/mL

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——

(-20℃)

With Ice Pack

≥ 2 years